When it comes to Apply/Save/Load, it doesn't matter what button I press, the same thing happens: the game freezes for a while, then the boxes I checked get unchecked. I tried looking up the internet for answers, but I don't think I've found topics with my exact issue.
I'm using Rudy's ENB, the latest version of ENB (0.407) and Mod Organizer 2, if that's important. I think I remember it not working the first time I tried, but it worked the second. The reason I mentioned DoF was that I actually managed to deactivate it way earlier in my "modding spree", back when I downloaded the ENB. Tried the same thing after putting it read-only, just in case. I tried editing the enbseries.ini directly, looks like the game just didn't read it. I tried toying with Depth of Field, didn't work either. I tried both ingame and on the main menu, didn't work. Unless I hit Save, in which case the same thing happens, except I only have to wait a few seconds. I tried using the ingame menu, but after I hit Apply (or Save, or Load), the game freezes for something like 20 seconds and the settings I'm trying to enable get unchecked. I'm currently trying to edit EnableComplexParticleLights and EnableBigRange in order to use Rudy's "More Lights for ENB" modifications, but it just won't work.